What is the significance of prostate pain? A lot of pain in the male pelvic region and even in the lower back can originate in the prostate gland. This is because nerve sensations from these areas are not localized. They can be felt over a wide area. It is similar to the ache one can feel in other teeth when a nearby tooth has a problem. A man might not feel an aching prostate where he thinks the prostate gland is located. He is just as likely to feel it in his testicles or his lower back. See more on prostate pain